CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells,聽and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack聽of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated聽by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 is a good聽immunohistochemical marker for T-cells. About 76% of T-cell neoplasms are reported to express CD5,聽and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma聽cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of聽malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare,聽is associated with a poor prognosis.
Alternative names: LEU1, T1
| Product Name: | Anti-CD5 Antibody |
|---|---|
| Reference #: | RU00028 |
| Clone #: | UMAB9 |
| Source #: | Mouse Monoclonal |
| Reactivity: | Human |
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